Evaluation of the Vitotox test as a high-throughput genotoxicity assay
نویسندگان
چکیده
منابع مشابه
High-Throughput Genotoxicity Testing
The registration of all pharmaceuticals requires a comprehensive safety assessment of their potential to cause direct or indirect genotoxic damage. This article reviews current methods employed for regulatory genotoxicity testing and new techniques developed for early high-throughput screening. A novel in vitro mammalian assay is described which detects all common mechanistic classes of genotox...
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Human contact to genotoxins is inevitable, as agents detrimental to our DNA are present in our environment, and also a result of our own cellular metabolism where they can contribute to cell death, gene mutations, and even cancer, disease and aging1,2,3,4. At the same time, therapeutic approaches such as chemotherapy and radiation treatment rely on initiation of tumor cell genotoxicity to produ...
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The ecological and health concern of mutagenicity and carcinogenicity potentially associated with an overwhelmingly large and ever-increasing number of chemicals demands for cost-effective and feasible method for genotoxicity screening and risk assessment. This study proposed a genotoxicity assay using GFP-tagged yeast reporter strains, covering 38 selected protein biomarkers indicative of all ...
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ژورنال
عنوان ژورنال: Environmental Mutagen Research
سال: 2003
ISSN: 0910-0865,1880-7054
DOI: 10.3123/jems.25.69